Ok, time to clear out a few misconceptions:
1. All brake fluid is synthetic. Really. Synthetic claims on the parts of manufacturers is marketing bull, pure and simple. That said, Valvoline and Castrol LMA are quality DoT-4 compliant fluids. I've used both with good results.
2. DoT-5 is a silicone based fluid that is NOT COMPATABLE with glycol based fluids. YOU CANNOT MIX THEM.
DoT-5 is inappropriate to use in any application unless:
a. You have completely flushed out all the brake fluid from the vehicle
b. The ABS system supports its usage.
I have experience converting a car to use DoT-5, a '73 VW. The advantage in that situation is that since the car sits for extended periods of time, and DoT-5 is not hygroscopic, that it will prevent internal corrosion of my brake parts from sitting.
I would not recommend converting an ABS-equipped vehicle to DoT-5 owing to the difficulty in removing all traces of fluid from the system, especially the ABS pump and BPMV. In my '73 VW, it was easy. I had all the brake components disassembled and rebuilt, and reassembled using DoT-5 as a lubricant. Does DoT-5 feel spongier? That's debatable. Seems fine in my '73 VW, which owing to the lack of power brakes on it, it feels differently than what I'm used to anyway.
3. DoT-5.1 is a glycol based fluid that has a higher dry and wet boiling point than the prior standard, DoT-4. The only advantage I see to using DoT-5.1 might be in a vehicle that is raced regularly on a track. Note that the dry boiling point of Castol LMA is greater around 504 degrees, IIRC, which comes awfully close to the 518 degrees required by the DoT-5.1 standard. You'll just end up paying more for DoT-5.1 for little advantage.